2021 Apr;20(4):309-325
Simon G, DiNardo CD, Takahashi K, Cascone T, Powers C, Stevens R, Allen J, Antonoff MB, Gomez D, Keane P, Suarez Saiz F, Nguyen Q, Roarty E, Pierce S, Zhang J, Hardeman Barnhill E, Lakhani K, Shaw K, Smith B, Swisher SG , High R, Futreal PA, Heymach J, Chin L
D-mannose alleviates osteoarthritis progression by inhibiting chondrocyte ferroptosis in a HIF-2-dependent manner
These offer enhanced patient convenience, potentially improving adherence in primary care and emerging markets
The practical takeaway is directional: the mechanism is real, the magnitude is individual, and the honest expectation is set with a provider who can weigh your history against what the label supports